Successful Treatment of Postkeratoplasty Fungal Keratitis with Topical and Intrastromal Voriconazole

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Successful Treatment of Postkeratoplasty Fungal Keratitis with Topical and Intrastromal Voriconazole

Objective: Corneal grafts have a major risk of fungal keratitis due to long-term local and sometimes systemic steroid/antibiotic use. The aim of this study was to evaluate the efficacy of intrastromal voriconazole as a therapeutic adjunctive for the management of fungal keratitis in corneal graft. Design: Presentation of two cases of fungal keratitis occurring after corneal transplantation and ...

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Topical and Oral Voriconazole in the Treatment of Fungal Keratitis

We describe two patients with fungal keratitis refractory to standard antifungal therapy whose conditions were managed with voriconazole. The first case is a patient with endophthalmitis and corneal ulcer due to Candida parapsilosis after receiving a corneal transplant. The patient was treated with amphotericin but showed no signs of improvement. Topical voriconazole, oral voriconazole, and int...

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Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit

Purpose. Evaluating the therapeutic effect of topical and intrastromal voriconazole and topical natamycin on Fusarium keratitis. Methods. 24 rabbits were selected. The stroma of their corneas was inoculated with suspension of Fusarium solani species complex. Seven days after injection they were divided into 4 groups randomly: the first group was treated with topical voriconazole (TV) 1% for one...

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Ineffectiveness of intrastromal voriconazole for filamentous fungal keratitis

PURPOSE The purpose of this study is to describe the ineffectiveness of intrastromal voriconazole injection for filamentous fungal keratitis by contrasting the effectiveness for yeast keratitis. METHODS We examined seven fungal keratitis patients prospectively. All yeast was identified by molecular phylogenetic analyses of the chromosomal regions coding for the D1/D2 domain of the large-subun...

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Successful treatment of Chrysosporium keratitis with voriconazole

OBJECTIVE To report a patient with severe Chrysosporium keratitis successfully treated by voriconazole. METHOD Case report. RESULTS A 37-year-old healthy male presented with irritation, pain and reduced vision in his left eye after mud contamination. Examination demonstrated corneal stromal infiltration, endothelial plaque and hypopyon. Corneal scrapings demonstrated numerous septate hyphae...

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ژورنال

عنوان ژورنال: Journal of Clinical & Experimental Ophthalmology

سال: 2015

ISSN: 2155-9570

DOI: 10.4172/2155-9570.1000393